Bioengineering, Cell therapy and Surgery in Congenital Malformations

During the last year, our research lines have focused on studying the causes of human congenital malformations, especially spina bifida and congenital diaphragmatic hernia, as well as on the study of musculoskeletal and osteoarticular pathologies and, in particular, on the development of new therapies based on advanced surgical techniques, cell therapy, biomaterials and 3D bioprinting to promote tissue regeneration for therapeutic purposes. Our team develops research with a great translational spirit to the human clinic, which has allowed our hospital to become a European reference center for prenatal repair of spina bifida and an internationally recognized team in the field of regenerative medicine and pediatric surgery.

eCORE

Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
Woman & Child Health & Rare Diseases

Team

Group Leader
Manuel López Paredes

Principal Investigator (PI)
Mario Marotta Baleriola, Carles Giné Prades, Francisco Soldado Carrera

Researchers
Ana Lain Fernandez, Gloria Fatou Royo Gomes, Romy Gander, José Andrés Molino Gahete, Sergio Lopez Fernandez, María Díaz Hervás, Marino Asensio Llorente, Montserrat Aguilera Pujabet, Josep Maria de Bergua Domingo

PhD Students
Laura Vidal Fornells, Ingrid Vila Fernández

Lab Technicians
Pamela Dominguez Baez, Esther Abadias Cortada, Anabel Sacristan Ruiz

Nursing and Technical Staff
No

Publications

50.0

%Q1

43.60

Impact Factor

4.36

Average Impact Factor

Cadaval C, Molino JA, Guillen G, Lopez Fernandez S, Hierro CL, Martos Rodriguez M, Khan HA, Vilardell E, Andreu E, Ruiz CW, Lopez M
Are Low Weight or Cardiopathy Contraindications for Thoracoscopic Repair of Esophageal Atresia with Tracheoesophageal Fistula?
Eur J Pediatr Surg. 2023 May 19.
DOI: 10.1055/a-2072-9754.
IF: 2.191

Gine C, Maiz N, Arevalo S, Rodo C, Lopez M, Carreras E.
Ruptured saccular limited dorsal myeloschisis: good indication for fetal repair.
Ultrasound Obstet Gynecol. 63(1):113-115.
DOI: 10.1002/uog.27457.
IF: 4.51

Garcia-Aguilar P, Maiz N, Rodo C, Garcia-Manau P, Arevalo S, Molino JA, Guillen G, Carreras E.
Fetal abdominal cysts: Predicting adverse outcomes.
Acta Obstet Gynecol Scand. 2023 Jul;102(7):883-890.
DOI: 10.1111/aogs.14584.
IF: 3.77

Jambrina-Abasolo U, Hutanu D, Gonzalez-Morgado D, Blasco-Casado F, Rojas-Neira J, Soldado F.
Shoulder extension impairment with residual neonatal brachial plexus injury.
J Shoulder Elbow Surg. 2023 Oct;32(10):2082-2088.
DOI: 10.1016/j.jse.2023.03.036.
IF: 3.3

Soldado F, Nguyen TQ, Gonzalez-Morgado D, Rojas-Neira J, Nguyen DH, Diaz-Gallardo P.
Extensor carpi radialis brevis motor branch transfer to the deep branch of the ulnar nerve to repair intrinsic hand palsy in neonatal lower brachial plexus and spinal cord injury
Microsurgery. 2023 Jul;43(5):512-515.
DOI: 10.1002/micr.31040.
IF: 1.96

Projects

TISSUE ENGINEERING FOR THE IMPROVEMENT OF THE FETOSCOPIC REPAIR OF OPEN SPINAL NEURAL TUBE DEFECTS IN OVINE FETUSES (TISSUE-NTD)
Principal Investigator: Nerea Maiz Elizaran
Agency: Instituto de Salud Carlos III
Funding: 135,520 €
Period: 2021-2025

Terapia celular para la regeneracion neural y el tratamiento del mielomeningocele en modelo experimental de feto de oveja.
Principal Investigator: Carlos Gine Prades
Agency: Instituto de Salud Carlos III
Funding: 83,490 €
Period: 2019-2023

Investigacion industrial de nuevas tecnologias para el tratamiento personalizado de patologias osteoarticulares de rodilla a traves de Inteligencia Artificial e implantes celularizados generados mediante bioimpresion 3D (BioprintIA)
Principal Investigator: Francisco Soldado Carrera
Agency: CENTRO PARA EL DESARROLLO TÉCNICO INDUSTRIAL (CDTI)
Funding: 153,300 €
Period: 2020-2023

3D Bioprinted personalised scaffolds for tissue regeneration of ankle joint (TRIANKLE).
Principal Investigator: Mario Marotta Baleriola
Agency: European Commission - H2020-NMBP-TR-IND-2020 (Grant agreement: 952981)
Funding: 713,750 €
Period: 2020-2024

Smart Bone Regeneration (SBR).
Principal Investigator: Mario Marotta Baleriola
Agency: European Commission - H2020- SC1-BHC-07-2019 (Grant agreement: 874896)
Funding: 835,000 €
Period: 2019-2023