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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group develops preclinical and clinical research in diagnosis and therapy of different diseases. Our scope of action ranges from the analysis of mass data from the Clinical Biochemistry service, the development of methods for the detection of diagnostic biomarkers and prognostics, the evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology. Currently, we have a team of more than 50 researchers working on 16 active competitive projects (4 of them awarded in 2023) led by 7 principal investigators. These projects have resulted in 90 publications during 2023, most of them published in journals of the first quartile of their specialization. At the teaching level, 3 doctoral theses have been defended during this year and we have tutored 2 master students.

eCORE

  • Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
  • Cancer
  • Woman & Child Health & Rare Diseases

Team

Group Leader
Ibane Abasolo Olaortua, Roser Ferrer Costa

Principal Investigator (PI)
Simó Schwartz Navarro, Joaquin Seras Franzoso, Francisco Rodríguez Frias, Rosanna Paciucci Barzanti, Diana Fernandes da Sousa Rafael

Researchers
Fernanda Raquel Da Silva Andrade, Zamira Vanessa Diaz Riascos, José Antonio Arranz Amo, Laura Conesa Milian, Joan López Hellin, Albert Blanco Grau, Clara Carnicer Cáceres, Jaume Vima Bofarull, Luisa Maria Martinez Sánchez, Fernando Moreno Flores, Joaquin Ruiz Altarejo, Pilar Reimundo Díaz-Fierros, Andrea Caballero Garralda, Imma Comas Reixach, Mª Pilar Felipe Fernandez

PhD Students
Diego Baranda Martínez-Abascal, Marc Miquel Moltó Abad, Clara Ramírez Serra, Yolanda Villena Ortiz, Pablo Gabriel Medina, Mª Teresa Gené Juyent,Verónica Villagrasa Araya, Maria Fidel Lledò, Daniel Bravo Nieto, Gonzalo González Silva, Alba Estela García Fernández, Sarai Garriga Edo, Andrea Arias Garcia, Laura Castellote Bellés, Laura Castillo Ribelles, Marina Giralt Arnaiz, Noelia Díaz Troyano,

Lab Technicians
Angels Alcina Mila, Laura García Latorre, Pilar Bonet Palomares, Sandra Mancilla Zamora, Belen Garcia Prats, Francisco Jesus Torralba Saban, Julia German Cortes

Nursing and Technical Staff
Maria del Carmen Sanchez Valcarcel, Mireia Benito Jimenez,

Publications

52
Publications
59.6
%Q1
391.30
Impact Factor
7.53
Average Impact Factor

González-Callejo P, Gener P, Díaz-Riascos ZV, Conti S, Cámara-Sánchez P, Riera R, Mancilla S, García-Gabilondo M, Peg V, Arango D, Rosell A, Labernadie A, Trepat X, Albertazzi L, Schwartz S Jr, Seras-Franzoso J, Abasolo I.
Extracellular vesicles secreted by triple negative breast cancer stem cells trigger pre-metastatic niche remodeling and metastatic growth in the lungs.
Int J Cancer. 2023 May 15;152(10):2153-2165.
DOI: 10.1002/ijc.34447
IF: 7.316

Giralt M, Díaz-Troyano N, Comas I, Blanco A, Conesa L, Mendoza M, Zafon C, Goya M, Ferrer R.
Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica IM Solution Immunoassay Analyzer.
Ann Clin Biochem. 2023 Dec 7:45632231219387
DOI: 10.1177/00045632231219387
IF: 2.2

Colomer-Castell S, Gregori J, Garcia-Cehic D, Riveiro-Barciela M, Buti M,Rando-Segura A, Vico-Romero J, Campos C, Ibañez-Lligoña M, Adombi CM, Cortese MF, Tabernero D, Esteban JI, Rodriguez-Frias F, Quer J.
In-Host HEV Quasispecies. Evolution Shows the Limits of Mutagenic Antiviral Treatments
Int J Mol Sci. 2023 Dec 6;24(24):17185.
DOI: 10.3390/ijms242417185
IF: 5.6

German-Cortes J, Vilar-Hernandez M, Rafael D, Abasolo I, Andrade F
Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment.
Pharmaceutics. 2023 Mar 3;15(3):831.
DOI: 10.3390/pharmaceutics15030831
IF: 6.52

Luengo Y, Diaz-Riascos ZV, Garcia-Soriano D, Teran FJ, Artes-Ibanez EJ, Ibarrola O, Somoza A, Miranda R, Schwartz S Jr, Abasolo I, Salas G
Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation.
Pharmaceutics. 2022 Jul 22;14(8). pii: pharmaceutics14081526.
DOI: 10.3390/pharmaceutics14081526.
IF: 6.52

Projects

MIMIC-KeY – A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES.
Principal Investigator: Ibane Abasolo Oloartua
Agency: European Comission
Funding: 457,250 €
Period: 2021-2025

(HEPAST) – Estrategias de terapia genica para controlar la infeccion por los virus de la Hepatitis B y Delta basada en el estudio de las cuasiespecies virales por secuenciación masiva
Principal Investigator: Francisco Rodríguez Frias
Agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 157,300 €
Period: 2022-2025

MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small Cell Lung Cancer
Principal Investigator: Ibane Abasolo Oloartua
Agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 333,099 €
Period: 2023-2026

Estudio multicéntrico de la reactividad de PSA de las vesículas extracelulares frente a inmunoensayos comerciales
Principal Investigator: Roser Ferrer Costa y Nerea Varo Cenarruzabeitia
Agency: Sociedad Española de Medicina de Laboratorio (SEQC-LM)
Funding: 20,000 €
Period: 2023-2025

Nanoclustered Affimers for Targeted KRAS Ablation in Pancreatic Ductal Adenocarcinoma
Principal Investigator: Joaquin Seras Franzoso y Diana Fernandes da Sousa Rafael
Agency: ACANPAN, AESPANC y AEG : VIII Becas Carmen Delgado/Miguel Pérez-Mateo
Funding: 50,000 €
Period: 2023-2025

Patents

METHOD FOR DETERMINING THE SUSCEPTIBILITY TO DEVELOP ASIA SYNDROME
Priority Number: EP23382738.5
Priority Date: 19/07/2023
Applicants: 60% VHIR/ 40% MIT TSU-INSTITUTE Amsterdam

FUNCTIONALIZED LIPOSOMES USEFUL FOR THE DELIVERY OF BIOACTIVE COMPOUNDS
Priority Number: P201231020
Priority Date: 29/06/2012
Applicants: 13.34% VHIR / 32 % CSIC / 24% PCB / 21.33 % CIBER-BBN / 5 % IRB / 1 % UB / 3.33 % UAB

CELL-PENETRATING PEPTIDES
Priority Number: EP20382968.4
Priority Date: 10/11/2020
Applicants: 100 % VHIR

A METHOD FOR DETECTING THE SUSCEPTIBILITY TO DEVELOP ADVERSE SIDE EFFECTS RELATED TO BIOIMPLANTS
Priority Number: P201030604
Priority Date: 27/04/2010
Applicants: 100 % VHIR

LIPOSOMES AND ITS USE FOR ENZYME DELIVERY
Priority Number: EP21382062.4
Priority Date: 27/01/2021
Applicants: 16 % VHIR/ 28% CSIC / 24 % CIBER / 16 % Nanomol Technologies S.L. / 16 % LEANBIO

VHIR Annual Report 2023