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Nephrology and kidney transplantation

In 2023, new research grants were obtained in the field of transplantation, basically 2 projects of technological and clinical importance. On the one hand, a CaixaImpulse grant for the further development of a bi-specific fusion protein to prevent transplant rejection and modulate the immune regulatory response and, on the other hand, a clinical project funded by Mutua Madrileña with the aim of achieving effective anti-HLA desensitization through the transplantation of hematopoietic progenitors by “resetting” adaptive immunity. On the other hand, the European Horizon2020 project HORUS has been initiated to evaluate the immunological response against cytomegalovirus. The group’s research has also been supported by 2 other competitive grants, one to evaluate the inflammatory infiltrates of renal implants using transcriptional spatial technology, as well as a grant for RRHH Rio Ortega to carry out the doctoral thesis.

eCORE

  • Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
  • Chronic, Prevalent Diseases & Aging
  • Personalized Medicine, Innovative Diagnostics, Molecular Imaging & Digital Health

Team

Group Leader
Oriol Bestard Matamoros, Maria José Soler Romeo

Principal Investigator (PI)
Francesc Moreso Mateos, Maria Antonia Emilia Meneghini, Irina Betsabé Torres Rodríguez, Elena Isabel Crespo Gimeno, Concepció Jacobs Cachá

Researchers
Delphine Kervella, Sheila Bermejo García, Irene Agraz Pamplona, M Antonieta Azancot Rivero, Manel Perelló Carrascosa, Natalia Ramos Terrades, Joana Sellarés Roig, Ander Vergara

PhD Students
Marian López Martínez, Nestor Gabriel Toapanta Gaibor, José Miguel Zuñiga Vergara, Gerson Berná, Claudia Carrera Muñoz, Juan Carlos León Román, Alba Torija Recasens, Laura Donadeu Casassas, Irene Martínez Díaz

Lab Technicians
Franc Casanova Ferrer, Núria Bolaños Peruga, Cristina Guirao Martínez, Mariona Juvé Torres, Cristina Font Miñarro, Carmen Llorens Cebrià

Nursing and Technical Staff
Emma Pardo de los Santos, Maria de Oreto Prat Canet, Alejandro Saiz Domenech, Yi Ji, Rosa Maria Pérez Garzón

Publications

61
Publications
57.4
%Q1
740.54
Impact Factor
12.14
Average Impact Factor

Yoo, D.; Goutaudier, V.; Divard, G.; Gueguen, J.; Astor, B.C.; Aubert, O.; Raynaud, M.; Demir, Z.; Hogan, J.; Weng, P.; Smith, J.; Garro, R.; Warady, B.A.; Zahr, R.S.; Sablik, M.; Twombley, K.; Couzi, L.; Berney, T.; Boyer, O.; Duong-Van-Huyen, J.P.; Giral, M.; Alsadi, A.; Gourraud, P.A.; Morelon, E.; Le Quintrec, M.; Brouard, S.; Legendre, C.; Anglicheau, D.; Villard, J.; Zhong, W.; Kamar, N.; Bestard, O.; Djamali, A.; Budde, K.; Haas, M.; Lefaucheur, C.; Rabant, M.; Loupy, A.
An automated histological classification system for precision diagnostics of kidney allografts
Nature Medicine 2023; 29 (5): 1211-1220
DOI: 10.1038/s41591-023-02323-6
IF: 82.900

Tambur, A.R.; Bestard, O.; Campbell, P.; Chong, A.S.; Barrio, M.C.; Ford, M.L.; Gebel, H.M.; Heidt, S.; Hickey, M.; Jackson, A.; Kosmoliaptsis, V.; Lefaucheur, C.; Louis, K.; Mannon, R.B.; Mengel, M.; Morris, A.; Pinelli, D.F.; Reed, E.F.; Schinstock, C.; Taupin, J.L.; Valenzuela, N.; Wiebe, C.;, Nickerson, P.
Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report
American Journal of Transplantation 2023; 23 (1): 133-149
DOI: 10.1016/j.ajt.2022.11.009
IF: 8.700

Bermejo, S.; González, E.; López-Revuelta, K.; Ibernon, M.; López, D.; Martín-Gómez, A.; Garcia-Osuna, R.; Linares, T.; Díaz, M.; Martín, N.; Barros, X.; Marco, H.; Navarro, M.I.; Esparza, N.; Elias, S.; Coloma, A.; Robles, N.R.; Agraz, I.; Poch, E.; Rodas. L.; Lozano, V.; Fernández-Fernández, B.; Hernández, E.; Martínez, M.I.; Stanescu, R.I.; Moirón, J.P.; García-Fernández, N.; Goicoechea, M.; Calero, F.; Bonet, J.; Liaño, F.; Pascual, J.; Bestard, O.; Praga, M.; Fulladosa, X.; Soler, M.J.
The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes
Clinical Kidney Journal 2023; 16 (10): 1656-1663
DOI: 10.1093/ckj/sfad142
IF: 4.600

Bestard, O.; Kaminski, H.; Couzi, L.; Fernández-Ruiz, M.; Manuel, O.
Cytomegalovirus cell-mediated immunity. Ready for routine use?
Transplant International 2023; 36: 11963
DOI: 10.3389/ti.2023.11963
IF: 3.100

Vergara, A.; Llorens-Cebrià, C.; Martos, N.; Martínez-Díaz, I.; Stein, F.; Domínguez-Báez, P.; Molina-Van den Bosch, M.; Rettel, M.; Benito, B.; Bermejo, S.; Pieper, M.P.; Jacobs-Cachá, C.; Soler, M.J.
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy
Clinical Science (Lond) 2023; 137 (1): 87-104
DOI: 10.1042/CS20220447
IF: 6.000

Projects

Caracterización en sangre periférica de una firma génica de rechazo humoral común en trasplantes de órganos sólidos
Principal Investigator: Maria Antonia Emilia Meneghini
Agency: Instituto de Salud Carlos III (ISCIII) - Proyectos de I+D+I en salud (PI22)
Funding: 111,320 €
Period: 2023-2025

Disección y promoción de inmunidad adaptativa específica frente al poliomavirus (BKV) para prevenir la infección viral tras el trasplante renal (proyecto BK-VAX)
Principal Investigator: Oriol Bestard Matamoros, Oriol, Elena Crespo Gimeno
Agency: Instituto de Salud Carlos III
Funding: 174,240 €
Period: 2023-2025

Manejo de la immunosupresión tras el fracaso de un injerto renal para prevenir de forma segura la sensibilización HLA: un estudio abierto, prospectivo multicéntrico y randomizado
Principal Investigator: Francesc Moreso Mateos, Irina Betsabé Torres Rodríguez
Agency: Instituto de Salud Carlos III - Convocatoria Proyectos Investigación Clínica Independiente
Funding: 495,326.55 €
Period: 2023-2026

Hacia un manejo clínico personalizado de pacientes oncológicos con fracaso renal agudo asociado a los immune-checkpointinhibitors (ICiS)
Principal Investigator: Maria José Soler Romeo
Agency: Instituto de Salud Carlos III
Funding: 246,840 €
Period: 2023-2025

Duacept, a novel bi-specific fusion protein to prevent transplant rejection
Principal Investigator: Oriol Bestard Matamoros
Agency: Fundació La Caixa - CaixaImpulse Innovation Programme
Funding: 148,500 €
Period: 2023-2025

Patents

Method for detecting antibody-secreting B cells specific for HLA
Priority Number: EP/04.06.14/EPA 14382214
Priority Date: 04/06/2015
Applicants: IDIBELL (100%)

Fusion protein with immunosuppressive activity
Priority Number: P4816EO00
Priority Date: 2019
Applicants: VHIR (50%), Bosch i Gimpera (50%)

Diagnosis of allograft rejection
Priority Number: P5489EP00
Priority Date: 2020
Applicants: VHIR (100%)

LABORATORY DEVICE FOR COLLECTING OF ANIMAL SAMPLES
Priority Number: 202131356
Priority Date: 29/06/2021
Applicants: VHIR (100%)

VHIR Annual Report 2023