eCORE
- Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
- Brain & Mind and Behaviour
- Chronic, Prevalent Diseases & Aging
Team
Group Leader
Miquel Vila Bover
Principal Investigator (PI)
Marta Martínez Vicente, Jordi Bové Badell, Jorge Hernández Vara, Ariadna Laguna Tuset, Oriol de Fabregues-Boixar Nebot
Researchers
Daniela Samaniego Toro, David Ramos Vicente, Javier Hoyo Pérez, Núria Peñuelas Peñarroya, Marta González Sepúlveda, Thais Cuadros Arasa, Mercedes Arrué Gonzalo
PhD Students
Silvia Enríquez Calzada, Tsakogias Iraklis, Alba Nicolau Vera, Anna Garcia Serra, Camille Guillard Sirieix, Eddie Pradas Gracia, Gerard Roch Alba, Joana Margalida Cladera Sastre, Maria Camprodon Gomez, Marina Lorente Picón, Marta Montpeyó Garcia-Moreno
Lab Technicians
Annabelle Parent, Jordi Riera Heredia, Maria Belen Garcé Rivarola, Pablo Castillo Sánchez, Maria Sellés Altés
Publications
Teil M, Dovero S, Bourdenx M, Arotcarena ML, Darricau M, Porras G, Thiolat ML, Trigo-Damas I, Perier C, Estrada C, Garcia-Carrillo N, Herrero MT, Vila M, Obeso JA, Bezard E, Dehay B.
Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
NPJ Parkinson’s Disease (2023) 9(1):135
DOI: 10.1038/s41531-023-00579-w
IF: 8.7
Gonzalez-Sepulveda M, Compte J, Cuadros T, Nicolau A, Guillard-Sirieix C, Peñuelas N, Lorente-Picon M, Parent A, Romero-Giménez J, Cladera-Sastre JM, Laguna A, Vila M
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease
Brain (2023) 146(3):1040-1052
DOI: 10.1093/brain/awac445
IF: 14.5
Chocarro J, Rico AJ, Ariznabarreta G, Roda E, Honrubia A, Collantes M, Peñuelas I, Vázquez A, Rodríguez-Pérez AI, Labandeira-García JL, Vila M, Lanciego JL
Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates
Brain (2023) 146(12): 5000-5014
DOI: 10.1093/brain/awad331
IF: 14.5
Oriol de Fàbregues, Maria Sellés, David Ramos-Vicente, Gerard Roch, Miquel Vila, Jordi Bové
Relevance of tissue‐resident memory CD8 T cells in the onset of Parkinson’s disease and examination of its possible etiologies: infectious or autoimmune?
Neurobiol Dis. 2023 Oct 15;187:106308
DOI: 10.1016/j.nbd.2023.106308
IF: 7.046
Diego Santos-García, Ariadna Laguna, Jorge Hernández-Vara , Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Iago García Díaz, Silvia Jesús, Maria Teresa Boungiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C Martínez Castrillo, Pilar Sánchez Alonso, Maria G Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Manuel Menéndez González, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Sex Differences in Motor and Non-Motor Symptoms Among Spanish Patients with Parkinson´s Disease
Journal of Clinical Medicine, 2023, Feb 7;12(4):1329
DOI: 10.3390/jcm12041329
IF: 4.96
Projects
Activity and connectivity drive neuronal vulnerability and disease progression in Parkinson’s disease
Principal Investigator: Miquel Vila
Agency: Michael J. Fox Foundation
Funding: $1,485,066
Period: 2021-2024
Molecular mechanisms of neuromelanin-linked neurodegeneration in Parkinson’s disease and brain aging
Principal Investigator: Miquel Vila
Agency: Spanish Ministry of Science and Innovation (MICINN, Spain)
Funding: 332,750 €
Period: 2021 - 2024
The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies
Principal Investigator: Marta Martinez-Vicente, Jorge Hernandez-Vara
Agency: Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (Spain)
Funding: 245,932.5 €
Period: 2021 - 2023
New nanotechnological therapy for Parkinson´s disease: nose to brain delivery of GBA-polymer nanoconjugates
Principal Investigator: Marta Martinez-Vicente
Agency: Obra Social Fundación la Caixa
Funding: 599,723 €
Period: 2022-2025
The Gut-Brain axis in patients with Parkinson’s disease: from pathophysiology to biomarkers and new therapeutic approaches
Principal Investigator: Ariadna Laguna
Agency: Instituto de Investigación Carlos III – Ministerio de Sanidad del Gobierno de España
Funding: 171,820 €
Period: 2022-2024
Patents
Glucocerebrosidase (GBA) polymer conjugate, preparation method and use for nanotechnological based Enzyme Replacement Therapy
Priority Number: PCT/EP2023/083626
Priority Date: 01/02/2024
Applicants: 100% VHIR
