- Differences between childhood and adult-onset eosinophilic esophagitis.
- Polygenic nature of irritable bowel syndrome and the genetic overlap between gastrointestinal and mental disorders.
- Prevalence of disorders of gut-brain interaction in Spain (Rome Foundation).
- Increased intestinal permeability and bacterial translocation in patients with fibromyalgia and chronic fatigue syndrome.
- Virtual reality-based self-administered psychological intervention for patients with gut-brain axis disorders.
- Treatment for fecal incontinence through non-instrumental biofeedback.
- Gut microbiota biomarkers related to clinical remission in IBD patients and to develop organoid models of IBD.
- Impact of biological therapy pharmacokinetics on clinical outcomes in IBD.
- Collaborative clinical research on acute and chronic pancreatitis and on pancreatic cancer, including artificial intelligence to diagnose early pancreatic cancer and the involvement of CFTR in the growth and spreading of pancreatic cancer.
eCORE
- Chronic, Prevalent Diseases & Aging
Team
Group Leader
Fernando Azpiroz Vidaur
Principal Investigator (PI)
Carmen Alonso Cotoner, Natalia Borruel Sainz, Danila Guagnozzi, Beatriz Lobo Álvarez, Carolina Malagelada Prats, Xavier Molero Richart, Virginia Robles Alonso, Jorge Serra Pueyo
Researchers
Ariadna Aguilar Cayuelas, Lara Aguilera Castro, Luís Gerardo Alcalá González, Claudia Barber Caselles, Claudia Herrera de Guise, Ronald Llerena Castro, Laura Campderros Traver, Stephanie Tasayco
PhD Students
Elena Céspedes Martínez, Adoración Nieto Ruíz, Xavier Serra Ruíz, Raquel Ibañez Ferrer
Lab Technicians
Elba Expósito Fernández
Nursing and Technical Staff
Sara Mendez Soriano, Elena Oller Jiménez, Zaira Pérez, Laura Polo Figueras, Ana María Rodríguez López
Publications
Rosell-Mases E, Santiago A, Corral-Pujol M, Yanez F, Varela E, Egia-Mendikute L, Arpa B, Cosovanu C, Panosa A, Serrano-Gomez G, Mora C, Verdaguer J, Manichanh C, Serrano-Gomez G, Manichanh C
Mutual modulation of gut microbiota and the immune system in type 1 diabetes models
Nat Commun. 2023 Nov 27;14(1):7770 Q1
DOI: 10.1038/s41467-023-43652-x
IF: 16.6
Damianos JA, Tomar SK, Azpiroz F, Barba E, Azpiroz F.
Abdomino-phrenic dyssynergia: a narrative review
Am J Gastroenterol. 2023 Jan 1;118(1):41-45.
DOI: 10.14309/ajg.0000000000002044.
IF: 12.045
Fierens L, Carney N, Novacek G, van der Woude CJ, Siegmund B, Casellas F, Borruel N, Huberts AS, Sonnenberg E, Gerold N, Primas C, Hedin CRH, Stamm T, Julsgaard M, Fiorino G, Simona R, Zini MLL, Gross E, Sander C, Arijs I, Vakouftsi VR, Koltai T, Charlafti I, Ferrante MCasellas F, Borruel N,
A Core Outcome Set for inflammatory bowel diseases: development and recommendations for implementation in clinical practice through an international multi-stakeholder consensus process.
J Crohns Colitis. 2023 Nov 29:jjad195.
DOI: 10.1093/ecco-jcc/jjad195.Q1
IF: 8
Rodino-Janeiro BK, Pigrau M, Salvo-Romero E, Nieto A, Exposito E, Gonzalez-Castro AM, Galan C, de Torres I, Pribic T, Hernandez L, Lobo B, Fortea M, Gallart M, Pardo-Camacho C, Guagnozzi D, Santos J, Alonso-Cotoner C Rodino-Janeiro BK, Pigrau M, Salvo-Romero E, Nieto A, Exposito E, Gonzalez-Castro AM, Galan C, de Torres I, Pribic T, Hernandez L, Lobo B, Fortea M, Gallart M, Pardo-Camacho C, Guagnozzi D, Santos J, Alonso-Cotoner C. .
Acute Stress Regulates Sex-Related Molecular Responses in the Human Jejunal Mucosa: Implications for Irritable Bowel Syndrome
Cells. 2023 Jan 27;12(3):423.
DOI: 10.3390/cells120304. Q2
IF: 7.666
Herrera-deGuise C, Varela E, Sarrabayrouse G, Pozuelo Del Rio M, Alonso VR, Sainz NB, Casellas F, Mayorga LF, Manichanh C, Vidaur FA, Guarner F, Herrera-deGuise C, Alonso VR, Casellas F, Manichanh C
Composition in Long-Remission Ulcerative Colitis is Close to a Healthy Gut Microbiota
Inflamm Bowel Dis. 2023 Sep 1;29(9):1362-1369
DOI: 10.1093/ibd/izad058.Q1
IF: 7.29
Projects
Fisiologia i fisiopatologia digestiva
Principal Investigator: Fco Javier Santos Vicente
Agency: AGAUR
Funding: 40,000 €
Period: 2022-2024
Desarrollo de programas telemáticos de intervención psicológica para el tratamiento de los trastornos funcionales digestivos.
Principal Investigator: Jorge Serra Pueyo
Agency: Instituto de Salud Carlos III
Funding: 135,520 €
Period: 2023-2025
Contribución de la disfunción de CFTR al desarrollo y agresividad del cáncer de páncreas. Estimulación del crecimiento tumoral y metástasis por células estrelladas carentes de CFTR
Principal Investigator: Francesc Xavier Molero Richard
Agency: Instituto de Salud Carlos III
Funding: 147,620€
Period: 2023 - 2025
Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in IRritable bowel syndrome In Europe (DISCOvERIE)
Principal Investigator: Fco Javier Santos Vicente
Agency: EUROPEAN COMMISSION
Funding: 1,148,684.84€
Period: 2020-2024
Contribución diferencial del epitelio intestinal a la fisiopatología de la diarrea crónica en el síndrome del intestino irritable y la colitis microscópica. Perfil clínico-biológico para el diagnóstico diferencial.
Principal Investigator: Maria Vicario Perez/Beatriz Lobo
Agency: Instituto de Salud Carlos III
Funding: 183,920 €
Period: 2020-2024
