Our research group has been predominantly focused on investigating biomarkers associated with the occurrence of epileptic seizures and those linked to impaired cognitive performance. In the current year, the group has actively pursued research in two competitive grants: one pertaining to biomarkers associated with the diagnosis of status epilepticus (PI19/01575) and the other targeting biomarkers predicting epilepsy in subarachnoid hemorrhage (FERP-2022-1). We successfully secured a predoctoral grant (García Dorado, 2 years), providing additional support to enhance various research avenues within the team.
In 2023, the group published 20 articles in peer-reviewed journals and presented its findings at national and international congresses through 45 communications. Furthermore, our group maintains a prominent position in recruiting subjects for international clinical trials related to epilepsy, actively participating in 16 ongoing trials.
eCORE
- Brain & Mind and Behaviour
Team
Group Leader
Estevo Santamarina Pérez
Principal Investigator (PI)
Manuel Toledo Argany, Laura Abraira del Fresno, Elena Fonseca Hernández
PhD Students
Daniel Campos Fernández, Samuel Lopez Maza, Sofía Lallana Serrano
Nursing and Technical Staff
Manuel Quintana Luque, Javier Sánchez López, Enric Bellido Castillo
Publications
Santamarina E, Rodrigo-Gisbert M, Abraira L, Campos-Fernández D, Quintana M, Gómez-Dabó L, Fonseca E, Lallana S, Toledo M.
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”
Epilepsia. 2023 Dec;64(12):3410-3411.
DOI: 10.1111/epi.17790.
IF: 5.6
Rodrigo-Gisbert M, Gómez-Dabó L, Quintana M, Campos-Fernández D, Lallana S, Fonseca E, Abraira L, Toledo M, Santamarina E.
Prediction of long-term unprovoked seizures after status epilepticus
Epilepsia. 2023 Sep;64(9):2399-2408.
DOI: 10.1111/epi.17697
IF: 5.6
Sinka L, Abraira L, Imbach LL, Zieglgänsberger D, Santamarina E, Álvarez-Sabín J, Ferreira-Atuesta C, Katan M, Scherrer N, Bicciato G, Terziev R, Simmen C, Schubert KM, Elshahabi A, Baumann CR, Döhler N, Erdélyi-Canavese B, Felbecker A, Siebel P, Winklehner M, von Oertzen TJ, Wagner JN, Gigli GL, Serafini A, Nilo A, Janes F, Merlino G, Valente M, Zafra-Sierra MP, Bayona-Ortiz H, Conrad J, Evers S, Lochner P, Roell F, Brigo F, Bentes C, Peralta AR, Pinho E Melo T, Keezer MR, Duncan JS, Sander JW, Tettenborn B, Koepp MJ, Galovic M.
Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model
JAMA Neurol. 2023 Jun 1;80(6):605-613.
DOI: 10.1001/jamaneurol.2023.0611
IF: 29
Toledano R, Villanueva V, Toledo M, Sabaniego J, Pérez-Domper P.
Toledano R, Villanueva V, Toledo M, Sabaniego J, Pérez-Domper P. Clinical and economic implications of epilepsy management across treatment lines in Spain: a real-life database analysis
J Neurol. 2023 Dec;270(12):5945-5957.
DOI: 10.1007/s00415-023-11958-x
IF: 6
Fonseca E, Sarria-Estrada S, Pareto D, Turon M, Quintana M, Santamarina E, Abraira L, Tortajada C, Rovira À, Toledo M.
Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy
Brain Imaging Behav. 2023 Feb;17(1):35-43.
DOI: 10.1007/s11682-022-00738-2
IF: 3.2
Projects
Estudio de biomarcadores relacionados con epilepsia en la hemorragia subaracnoidea (FERP-2022-1)
Principal Investigator: Laura Abraira del Fresno
Agency: Fundación Eugenio Rodríguez Pascual
Funding: 24,990 €
Period: 2023-2024
Uso de marcadores en la detección de crisis epilépticas de mal pronóstico (PI19/01575)
Principal Investigator: Estevo Santamarina
Agency: Instituto de Salud Carlos III
Funding: 73,810 €
Period: 2020-2024
Plataforma personalitzada per l’anàlisi de fàrmacs antiepilèptics (2021 LLAV 00014)
Principal Investigator: Miguel Chillón
Agency: AGAUR. Modalitat A. Llavor Indústria del Coneixement.
Funding: 20,000 €
Period: 2022-2023
Evaluación multimodal mediante biomarcadores para la predicción y manejo personalizado de la epilepsia secundaria a subaracnoidea aneurismática
Principal Investigator: Estevo Santamarina Pérez
Agency: Fundació Institut de Recerca HUVH
Funding: 117,000 €
Period: 2023-2025
Detección precoz del deterioro cognitivo en pacientes con epilepsia de reciente diagnóstico
Principal Investigator: Elena Fonseca Hernández
Agency: Aula Vall d'Hebron
Funding: 35,000 €
Period: 2022-2023
