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Rheumatology

IMIDomics, a VHIR spinoff cofounded by S Marsal, has established new contracts of research collaboration with pharmaceutical & biotech companies. S Marsal won a Trifermed Award for Social Impact in Healthcare. H2020 EU project DoCTIS coordinated by Marsal and Julià, has initiated CT Trial validation. A pioneering study with CAR T-cell therapy for SLE recruited first world-wide patient (Cortés). Trallero & VHIO co-leading a national project on IMID patients treated with checkpoint inhibitors. H2020 EU Projects: DarkMatter-NCD (Julià), DISCOvERIE-IBS (Alegre, Castro). FIS-ISCIII (PIs: Trallero, López Lasanta, Marsal). SER Award in FM (Almirall), Agustí Pi i Sunyer BSciences Award in SLE (Solé), SCR Scholarship in SSjögren (Gómez). Thesis dissertations: Michelena, López Corbeto. Research Intensification contract (Trallero). IMID-Biobank (Tortosa) collecting longitudinal IMID patients, new IMIDs. CT Rheumatology Unit (Sender) growing in all research lines. 46 publications in peer-review.

eCORE

  • Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
  • Chronic, Prevalent Diseases & Aging

Team

Group Leader
Antonio Julia Cano

Principal Investigator (PI)
Josefina Cortés, Ernesto Trallero, José Alegre, Juan José de Agustín de Oro, María López, Cristina Solé, Jesús Castro, Adrià Aterido, Jordi Lladós, Nuria Palau, Raül Tortosa

Researchers
Mireia Barceló, Alba Erra, Andrea Pluma, Ramón Sanmartín, Miriam Almirall, Mayte Serrat, Mireia López, Xabier Michelena, Alejandro Gómez, Estefanía Moreno

PhD Students
Luis Coronel, Helena Borrell, Rafael Touriño, María Pascual, Esther Espartal, Sebastián Sandoval, Judith Fernández

Lab Technicians
Edgar Núñez, Aitor Ruiz, Erica Téllez, Blanca Joseph

Nursing and Technical Staff
Montserrat Sender, Hugo Fernando Ávalos, Ana Daniela Ulloa, Carlos Jorge Alcaraz, Adriana Cabrera, Natalia Nogué, Carlos Junco, Alba Frias, Ares Sellés, Josep Masramón, Viviana Sánchez, María Royo, Edgar Núñez, Aitor Ruiz, Erica Téllez, Blanca Joseph, Marta Musté, Ana Roig, Natalia Boix, Mercè Fabregat, Elena Granell

Publications

47
Publications
53.2
%Q1
355.60
Impact Factor
7.57
Average Impact Factor

COVID-19 Host Genetics Initiative (Marsal S, Julià A)
COVID-19 Host Genetics Initiative. A second update on mapping the human genetic architecture of COVID-19
Nature. 2023 Sep;621(7977):E7-E26
DOI: 10.1038/s41586-023-06355-3
IF: 64.8

Pinal-Fernandez I, Quintana A, Milisenda JC, Casal-Dominguez M, Muñoz-Braceras S, Derfoul A, Torres-Ruiz J, Pak K, Dell'Orso S, Naz F, Gutierrez-Cruz G, Milone M, Shelly S, Duque-Jaimez Y, Tobias-Baraja E, Matas-Garcia A, Garrabou G, Padrosa J, Ros J, Trallero-Araguás E, Walitt B, Christopher-Stine L, Lloyd TE, Zhao C, Swift S, Rajan A, Grau-Junyent JM, Selva-O'Callaghan A, Liewluck T, Mammen AL
Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis
Ann Rheum Dis. 2023 Jun;82(6):829-836
DOI: 10.1136/ard-2022-223792
IF: 27.4

Khairani CD, Bejjani A, Piazza G, Jimenez D, Monreal M, Chatterjee S, Pengo V, Woller SC, Cortes-Hernandez J, Connors JM, Kanthi Y, Krumholz HM, Middeldorp S, Falanga A, Cushman M, Goldhaber SZ, Garcia DA, Bikdeli B
Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes: Meta-Analysis of Randomized Trials
J Am Coll Cardiol. 2023 Jan 3;81(1):16-30
DOI: 10.1016/j.jacc.2022.10.008
IF: 24.4

Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, Castro-Marrero J.
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
Nutrients 2023; 15(21):4504
DOI: 10.3390/nu15214504
IF: 5.9

Projects

Decision on optimal combinatorial therapies in IMIDs using systems approaches. DOCTIS
Principal Investigator: Sara Marsal Barril
Agency: European Comission H2020. H2020-SCH1-BHC-02-2019. https://cordis.europa.eu/project/id/848028
Funding: 6,260,050 €
Period: 01/01/2020 – 31/12/2025

Artritis reumatoide: de la fase preclínica a la enfermedad activa. Caracterización de los cambios sistémicos y en el tejido sinovial en el establecimiento de la enfermedad ACPA-positiva
Principal Investigator: Sara Marsal Barril / María López Lasanta
Agency: Instituto de Salud Carlos III (PI23/01372)
Funding: 250,000 €
Period: 01/01/2023 - 01/01/2026

Caracterización de las células patogénicas del músculo y piel de pacientes con Dermatomiositis y Síndrome Antisintetasa y estudio de aplicabilidad traslacional.
Principal Investigator: Ernesto Trallero Araguas
Agency: Instituto de Salud Carlos III (PI22/00708)
Funding: 135,520 €
Period: 01/01/2023 - 31/12/2025

Sjögren Syndrome and Atopic Dermatitis cohorts’ generation and multi-omics characterization (SSAD project)
Principal Investigator: Sara Marsal Barril, José Luis Andreu, Josep Manuel Carrascosa
Agency: IMIDomics Inc.
Funding: 1,680,000 €
Period: 26/06/2023– 26/06/2025

Inmunomonitorización personalizada para estratificar los pacientes con lupus eritematoso sistémico
Principal Investigator: Cortes Hernández, Josefina
Agency: Instituto de Salud Carlos III (PI21/00287)
Funding: 141.570€
Period: 01/01/2022 - 31/12/2024

Patents

METHOD TO PREDICT THE LACK OF RESPONSE TO ANTI-TNF ALPHA THERAPIES
Priority Number: PCT/EP2014/066604 (US)
Priority Date: 1/08/2014
Applicants: 66% VHIR, 33,3 % H. Clínic

RISK LOCUS FOR PSORIATIC ARTHRITIS
Priority Number: 62/151,952 (PCT)
Priority Date: 23/04/2015
Applicants: VHIR, CLINIC, IGTP

METHOD TO PREDICT RESPONSE TO TREATMENT WITH ANTI-TNF ALPHA AGENTS
Priority Number: EP14179452.9 (PCT)
Priority Date: 1/08/2014
Applicants: VHIR

Pronóstico de respuesta al tratamiento con anti-TNFalfa en pacientes de artritis reumatoide
Priority Number: P201330650 (PCT)
Priority Date: 3/05/2013
Applicants: VHIR

METODO IN VITRO Y KIT PARA EL PRONOSTICO O PREDICCION DE LA RESPUESTA POR PARTE DE PACIENTES CON ARTRITIS REUMATOIDE AL TRATAMIENTO CON AGENTES BLOQUEANTES DEL FACTOR TNF alfa (INFLIXIMAB)
Priority Number: P200802713 (ES)
Priority Date: 24/09/2008
Applicants: VHIR

VHIR Annual Report 2023