Transfusion medicine encompasses various care and research lines around immunohematology, cellular immunotherapy, congenital coagulopathies and regenerative medicine.
A. Obtaining red blood cells generated in vitro to enhance the panel of blood donors with minority blood groups. N Nogues group has established a technology for immortalization of red blood cell lines to improve panels.
B. Technological improvements for diagnosis of hereditary haemorrhagic diseases. F Vidal group has developed and validated new NGS technologies in the study of these disorders.
C. Creation of a bank of T cells. S Querol group is developing strategies for generation and ex vivo production of T lymphocytes to treat infectious and oncohematological diseases.
D. Blood safety. S Sauleda group is conducting epidemiological surveillance on emerging and re-emerging transfusion-transmitted infectious diseases and is developing immunological and molecular tools to better understand their physiopathology.
eCORE
- Advanced Therapies and Advanced Interventions, Nanomedicine, Transplant & Donation
Team
Group Leader
Rafael Parra López
Principal Investigator (PI)
Francisco Vidal Perez, Nuria Nogues Galvez, Sergi Querol Giner
Researchers
Sofia Alonso Mateos, Gemma Aran Canals, Carmen Azqueta Molluna, Marta Bes Maijo, Nina Borràs Agustí, Laia Closa Gil, Margarita Codinach Creus, Irene Corrales Insa, Joaquim Delgadillo Duarte, Emma Enrich Rande, Rubén Escribá Piera, Elisenda Farssac Busquets, Jesus Fernandez Sojo, Iris Garcia Martínez, Cecilia González Santesteban, Maria Jose Herrero Mata, Carlos Hobeich Naya, Sergio Huertas Torres, Mónica Linares Alberich, Laura Martin Fernandez, Lluis Martorell Cedres, Laia Miquel Serra, Rut Mora Buch, Sara Morini, Helena Pasamar Garijo, Maria Madeleine Piron, Vanesa Pleguezuelos Hernandez, Cristina Prat Vidal, Marina Rierola Carrera, Luciano Rodríguez Gómez, Francesc Rudilla Salvador, Dinara Samarkanova, Silvia Sauleda Oliveras, Gloria Soria Guerrero
PhD Students
Verónica Pons Escoll, Sílvia Torrents Zapata, Elena Valdivia Garcia
Lab Technicians
Natàlia Comes Fernández, Carina Lera Asensio, Lorena Ramirez Orihuela, Angie Rico Blazquez
Nursing and Technical Staff
Merce Albert Bayo, Isabel Amaya Aguilar, Neus Boto Ruiz, Maria Cristina Caparros Felipe, Carles Caro Pauon, Maria Teresa Contijoch Mateos, Núria Font Cotet, Raquel Gil Muro, Marta Guerrero Parés, Fran Martinez Paneque, Carmen Montanero Gallardo, Enric Pàmies Barcons, Juan Manuel Porras Paradas, Maria Esperanza Ribas Badia, Marc Vilches Martinez
Publications
Martin-Fernandez L, Garcia-Martínez I, Lopez S, Martinez-Perez A, Vilalta N, Plaza M, Moret C, Viñuela A, Brown AA, Panousis NI, Buil A, Dermitzakis ET, Corrales I, Souto JC, Vidal F, Soria JM
Multiallelic Copy Number Variation in ORM1 is Associated with Plasma Cell-Free DNA Levels as an Intermediate Phenotype for Venous Thromboembolism
THROMB HAEMOST 2023 Jan 25.
DOI: 10.1055/s-0043-1760844.
IF: 6.7
Delgadillo J, Kerkelä E, Waters A, Akker EVD, Lechanteur C, Baudoux E, Gardiner N, De Vos J, Vives J.
A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe
CYTOTHERAPY. 2023 Sep 5:S1465-3249(23)01015-0.
DOI: 10.1016/j.jcyt.2023.08.001
IF: 4.5
Torrents S, Del Moral AE, Codinach M, Rodríguez L, Querol S, Vives J
Optimized reagents for immunopotency assays on mesenchymal stromal cells for clinical use
IMMUNOL RES. 2023 Apr 29:1–10.
DOI: 10.1007/s12026-023-09385-1
IF: 4.4
Martorell L, López-Fernández A, García-Lizarribar A, Sabata R, Gálvez-Martín P, Samitier J, Vives J.
Preservation of critical quality attributes of mesenchymal stromal cells in 3D bioprinted structures by using natural hydrogel scaffolds.
BIOTECHNOL BIOENG. 2023 Mar 14.
DOI: 10.1002/bit.28381.
IF: 3.8
Sauleda S, Bes M, Piron M, Ong E, Coco SB, Carrió J, Linnen JM.
Clinical performance of a new multiplex assay for the detection of HIV-1, HIV-2, HCV, HBV, and HEV in blood donations in Catalonia (Spain).
TRANSFUSION. 2023 Sep 28.
DOI: 10.1111/trf.17518.
IF: 2.9
Projects
Lab-grown red cells for the transfusion management of vaso-occlusive crisis in sickle cell patients
Principal Investigator: Núria Nogues
Agency: Fundació La Caixa
Funding: 666,226 €
Period: 2023-2026
LAB-REDCELL: Lab-grown red cells from immortalized erythroid cell lines as an alternative source of red cells with rare phenotypes for diagnostic and therapeutic applications
Principal Investigator: Núria Nogues
Agency: AEI
Funding: 156,250 €
Period: 2023-2027
Development of a dual CD1a/CCR9-directed CAR-T therapy for the treatment of R/R T-cell Acute Lymphoblastic Leukemia
Principal Investigator: Sergi Querol
Agency: AEI
Funding: 281,970 €
Period: 2023-2026
OSCAR-iNK: Off-the-Shelf iPSC-derived next generation CAR-NK cells for solid tumor allogenic immunotherapy
Principal Investigator: Sergi Querol
Agency: AEI
Funding: 97,632 €
Period: 2022-2025
HEMO-GAS. Recreating the embryonic niche for hematopoietic stem cell production and derivatives in human gastruloids
Principal Investigator: Núria Nogues
Agency: AEI
Funding: 120,374 €
Period: 2021-2024
